Urinary proteins detected using modern proteomics intervene in early type 2 diabetic kidney disease-a pilot study. Golea-Secara, A., Munteanu, C., Sarbu, M., Cretu, O.M., Velciov, S., Vlad, A., Bob, F., Gadalean, F., Gluhovschi, C., Milas, O., et al. Extracellular vesicles in renal diseases: more than novel biomarkers? J Am Soc Nephrol 27, 12–26. Nonproteinuric diabetic nephropathy: when diabetics don’t read the textbook. Plasma cathepsin D activity rather than levels correlates with metabolic parameters of type 2 diabetes in male individuals. Science 285, 245–248.ĭing, L., Houben, T., Oligschlaeger, Y., Bitorina, A.V., Verwer, B.J., Tushuizen, M.E., and Shiri-Sverdlov, R. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Myosins are differentially expressed under oxidative stress in chronic streptozotocin-induced diabetic rat brains. ACE2 and diabetes: ACE of ACEs? Diabetes 59, 2994–2996.Ĭalabria, L.K., Vieira da Costa, A., da Silva Oliveira, R.J., Ramos Deconte, S., Nascimento, R., de Carvalho, W.J., de Oliveira, V.N., Arcaro Filho, C.A., Rezende Alves de Oliveira, L., Goulart, L.R., et al. Metabolites 10, 482.īatlle, D., Jose Soler, M., and Ye, M. Optimisation of urine sample preparation for headspace-solid phase microextraction gas chromatography-mass spectrometry: altering sample pH, sulphuric acid concentration and phase ratio. The results of our study comprehensively elucidated the changes in the urinary proteome and revealed several potential biomarkers reflecting the progression of DKD, which provide a reference for DKD biomarker screening.Īggarwal, P., Baker, J., Boyd, M.T., Coyle, S., Probert, C., and Chapman, E.A. A series of potential biomarkers, such as SERPINA1 and transferrin (TF), were detected and validated to be used for DKD diagnosis or disease monitoring. The dynamics analysis of the urinary and exosome proteomes in our study provides a valuable resource for discovering potential urinary biomarkers in patients with DKD. In this study, to comprehensively elucidate the molecular characteristics of urinary proteins and urinary exosome proteins in type 2 DKD, we performed large-scale urinary proteomics ( n=144) and urinary exosome proteomics ( n=44) analyses on T2DM patients with albuminuria in varying degrees. Monitoring the early diagnostic period and disease progression plays a crucial role in treating DKD. Diabetic kidney disease (DKD) is a major microvascular complication of type 2 diabetes mellitus (T2DM).
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